Found 22 matching trials
A Study of Tucatinib (ONT-380) Combined With Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2+ Breast Cancer
PHASE1The purpose of this study is to determine the maximal tolerated dose (MTD) ...
Location
University of Alabama
Tucatinib Together With Pembrolizumab and Trastuzumab
PHASE2Women or men with HER2-positive, metastatic breast cancer, who have progres...
Location
Coffs Harbour Health Campus
Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer
PHASE1This phase Ib/II trial studies the side effects and best dose of ribociclib...
Status
Active Not Recruiting
Location
UCLA / Jonsson Comprehensive Cancer Center
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
PHASE2A phase 2 non-randomized study to assess the safety and efficacy of the com...
Location
University of Alabama at Birmingham
Tucatinib and Trastuzumab in HER3-mutant and HER2-not Amplified Metastatic Breast Cancer
PHASE2The H3RAKLES trial would allow patients with a progressive metastatic breas...
Location
Polyclinique Bordeaux Nord Aquitaine
Phase Ib/II Study of Zanidatamab Plus Tucatinib and Chemotherapy in HER2-Positive Advanced Breast Cancer
PHASE1The JAZMINE study is a multicenter, open-label, non-comparative, phase Ib/I...
Location
Multiple Locations
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
PHASE3This study is being done to find out if tucatinib with other cancer drugs w...
Location
Palo Verde Hematology Oncology
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
PHASE3This study is being done to see if tucatinib with ado-trastuzumab emtansine...
Status
Active Not Recruiting
Location
University of South Alabama Health Children's and Women's Hospital
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
PHASE1DESTINY-Breast07 will investigate the safety, tolerability, and anti-tumour...
Status
Active Not Recruiting
A Safety, Tolerability, and Pharmacokinetic Study of Tucatinib in Healthy Japanese and Caucasian Subjects
PHASE1This study is being done to compare the pharmacokinetics (PK) and safety/to...
Location
PAREXEL International, Early Phase Clinical Unit - Los Angeles